Armodafinil or Modafinil – What is the Difference?

Modafinil and Armodafinil are similar smart drugs used to increase energy and improve concentration and alertness. Modafinil (brand name Provigil) was developed in 1994 to treat narcolepsy. Armodafinil (brand name Nuvigil) has only been introduced in 2007. Armodafinil is similar to Modafinil and has only slightly modified chemical structure, making it more potent. So which is better as a smart drug (nootropic) – Armodafinil or Modafinil?

They both are used to treat same conditions and are very effective. While Armodafinil requires a smaller dosage, Modafinil effects may still be preferred by some users. Asking which is better discounts the fact that different drugs can have different reactions for different people. Potency is not the only factor, what matters more is the experience you receive when using a smart drug.


For users who suffer from narcolepsy, sleep apnea, or other sleep problems, Modafinil was the first medication to actually provide real relief. The pill helps to normalize sleep and acts as a wakefulness agent, allowing users to go about their lives without constant fatigue. Modafinil is often used off label to increase energy and focus.

Reviews from users say Modafinil gives them dramatically improved focus and productivity. Along with this intense focus comes an increased fluency or fluidity of thought. Even ordinary tasks like reading and writing require much less effort or attention. It is easier to make connections and recall memories and retention is also higher. Some report improved sensory perceptions and even appetite suppression.


Armodafinil benefits are similar to those of Modafinil. The wakefulness effect is very pronounced, like a dose of caffeine, but unlike caffeine there are no jitters or nervousness and it does not increase (nor decrease) blood pressure or pulse rate. Armodafinil is quite safe and has almost zero addictiveness (Modafinil does have a slightly higher potential for side effects and tolerance).

Unlike Modafinil, Armodafinil will not disturb your sleep patterns. Even after using the supplement you will not have a sudden drop off and will be able to go to sleep the same time as normal. You will also wake up at your regular hours. Modafinil users say often it is impossible to sleep within 5-10 hours after taking a pill. In some regard this can be a negative if a user is looking for a drug that helps him stay awake for long hours.

Armodafinil also improves focus, but it isn’t as intense as Modafinil for most users. This makes Armodafinil better suited for continuous use as opposed to Modafinil which should be cycled or used occasionally. Armodafinil certainly improves productivity and also often boosts memory and mental fluidity. It has only been available for a few years, but already more than 2 million prescriptions were written and its being taken by all types of people ranging from entrepreneurs to athletes, from students to shift workers.

Armodafinil vs Modafinil:

The difference between these two nootropics is in their chemical structure. Armodafinil is an enantiomer of Modafinil. This means that Armodafinil consist of only the (R)-enatiomer which is the active component of Modafinil. Modafinil has both left and right-handed enantiomers in its structure. Consisting of only right enantiomer Armodafinil is basically a purified version of Modafinil. Consequently, it binds differently to receptor sites within the brain and body. While Modafinil dosage is 200mg, only 150mg of Armodafinil are needed to get the same effect.

There are differences between how these drugs will affect you, but most differences are dependent on the person who is actually taking the drugs. Some reviews say that Modafinil has a bigger mood enhancement effect, improving confidence and drive. Same users find that Armodafinil makes them feel a little edgy and a bit aggressive. These difference are not expressed for everyone and should be taken as an indication of where differences might be noticed.

Important issue to consider is tolerance. While many people have taken these drugs for a long period of time without any noticeable drop off in effects, others observed that tolerance can build quite quickly. Tolerance also seems to be more associated with Modafinil than Armodafinil. This can be overcome by cycling or only using Modafinil on occasion.

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